Christoph Sarrazin Selected Research

Chronic Hepatitis C

1/2023	The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection.
1/2022	Elevated liver enzymes predict morbidity and mortality despite antiviral cure in patients with chronic hepatitis C: Data from the German Hepatitis C-Registry.
10/2021	Weight Gain after Interferon-Free Treatment of Chronic Hepatitis C-Results from the German Hepatitis C-Registry (DHC-R).
1/2021	Failure on voxilaprevir, velpatasvir, sofosbuvir and efficacy of rescue therapy.
9/2020	Sofosbuvir, velpatasvir, and voxilaprevir for patients with failure of previous direct-acting antiviral therapy for chronic hepatitis C: Results from the German Hepatitis C-Registry (DHC-R).
7/2020	Treatment outcomes in hepatitis C virus genotype 1a infected patients with and without baseline NS5A resistance-associated substitutions.
4/2020	Treatment-failure to direct antiviral HCV regimens in real world: frequency, patient characteristics and rescue therapy - data from the German hepatitis C registry (DHC-R).
1/2019	Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants.
1/2019	Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.
12/2018	HCV core antigen as an alternative to HCV RNA testing in the era of direct-acting antivirals: retrospective screening and diagnostic cohort studies.

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Christoph Sarrazin Research Topics

Disease

100	Infections 03/2024 - 12/2002
85	Chronic Hepatitis C 01/2023 - 12/2002
43	Fibrosis (Cirrhosis) 01/2022 - 05/2004
39	Hepatitis C 12/2022 - 07/2003
20	Liver Diseases (Liver Disease) 01/2022 - 09/2006
17	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 03/2008
11	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 02/2010
9	Viremia 01/2017 - 06/2004
8	Virus Diseases (Viral Diseases) 01/2023 - 01/2005
8	Hepatitis B 04/2022 - 08/2005
8	Chronic Hepatitis B 07/2019 - 08/2005
5	Pathologic Constriction (Stenosis) 01/2016 - 03/2013
4	Coinfection 05/2024 - 03/2012
4	End Stage Liver Disease 07/2017 - 01/2013
3	Persistent Infection 01/2020 - 10/2011
3	Disease Progression 12/2019 - 08/2006
3	Reinfection 11/2019 - 08/2011
3	HIV Infections (HIV Infection) 01/2018 - 05/2015
3	Hemorrhage 01/2014 - 04/2012
2	Non-alcoholic Fatty Liver Disease 08/2023 - 07/2014
2	Lactic Acidosis 04/2016 - 12/2009
2	Hepatitis A (Hepatitis, Infectious) 01/2016 - 08/2014
2	Sclerosing Cholangitis 01/2016 - 01/2015
2	Body Weight (Weight, Body) 01/2015 - 06/2004
2	Vitamin D Deficiency 10/2013 - 05/2011
1	COVID-19 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Mental Disorders (Mental Disorder) 01/2022
1	Acute-On-Chronic Liver Failure 12/2021

Drug/Important Bio-Agent (IBA)

77	Antiviral Agents (Antivirals)IBA 03/2024 - 05/2004
45	Ribavirin (Virazole)FDA LinkGeneric 01/2021 - 12/2002
30	InterferonsIBA 10/2021 - 01/2006
28	RNA (Ribonucleic Acid)IBA 12/2018 - 03/2003
22	Interferon-alpha (Interferon Alfa)IBA 04/2016 - 12/2002
14	telaprevirIBA 06/2018 - 09/2007
11	SofosbuvirIBA 03/2024 - 05/2014
11	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2010
9	Protease Inhibitors (Protease Inhibitor)IBA 01/2019 - 09/2007
9	N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA 06/2018 - 04/2007
6	SphingolipidsIBA 01/2023 - 07/2014
6	Alanine Transaminase (SGPT)IBA 01/2022 - 01/2011
6	Hepatitis B e AntigensIBA 01/2020 - 08/2006
6	Vitamin D FDA LinkGeneric 10/2018 - 05/2011
6	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 08/2005
5	AntigensIBA 07/2019 - 06/2009
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 08/2004
5	Interferon LambdaIBA 10/2017 - 01/2013
4	EnzymesIBA 08/2023 - 07/2014
4	BilirubinIBA 11/2021 - 12/2009
4	SimeprevirIBA 05/2019 - 05/2014
4	Tenofovir (Viread)FDA Link 02/2019 - 08/2006
4	faldaprevirIBA 01/2016 - 05/2014
4	CholesterolIBA 03/2015 - 11/2010
4	hydroxide ionIBA 12/2014 - 05/2011
4	NucleosidesIBA 05/2014 - 01/2010
3	Lamivudine (Epivir)FDA Link 07/2019 - 08/2005
3	sofosbuvir drug combination ledipasvirIBA 05/2019 - 01/2016
3	daclatasvirIBA 05/2019 - 05/2014
3	ledipasvirIBA 11/2018 - 01/2016
3	Transaminases (Aminotransferases)IBA 06/2018 - 01/2011
3	SphingosineIBA 06/2016 - 07/2014
3	HCV NS3-4A Protease InhibitorsIBA 01/2015 - 01/2012
3	NucleotidesIBA 06/2013 - 09/2009
3	adefovirIBA 03/2012 - 08/2005
2	voxilaprevirIBA 03/2024 - 01/2021
2	velpatasvirIBA 03/2024 - 01/2021
2	glecaprevir and pibrentasvirIBA 01/2022 - 01/2021
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022 - 01/2021
2	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2021 - 01/2012
2	VaccinesIBA 11/2019 - 08/2014
2	ombitasvirIBA 05/2019 - 01/2018
2	Calcitriol (Calcijex)FDA LinkGeneric 10/2018 - 01/2012
2	safingol (sphinganine)IBA 06/2016 - 03/2015
2	Lactic Acid (Lactate)FDA LinkGeneric 04/2016 - 12/2009
2	Viral RNAIBA 01/2016 - 02/2013
2	oxidized low density lipoproteinIBA 01/2016 - 05/2015
2	deleobuvirIBA 01/2016 - 01/2016
2	LipidsIBA 12/2015 - 11/2010
2	Peptide Hydrolases (Proteases)FDA Link 11/2015 - 12/2008
2	Ferritins (Ferritin)IBA 05/2015 - 09/2007
2	AcidsIBA 01/2015 - 07/2014
2	IronIBA 07/2014 - 09/2007
2	Amantadine (Aman)FDA LinkGeneric 01/2013 - 01/2006
2	Amino Acids FDA Link 06/2012 - 01/2006
2	CreatinineIBA 04/2012 - 12/2009
2	entecavir FDA Link 03/2012 - 12/2009
2	peginterferon alfa-2b (Pegintron)FDA Link 11/2011 - 06/2004
2	Keratin-18 (Keratin 18)IBA 11/2011 - 01/2007
2	adefovir dipivoxil (Hepsera)FDA Link 08/2006 - 08/2005
2	Interleukin-8 (Interleukin 8)IBA 01/2005 - 05/2004
1	bulevirtideIBA 05/2024
1	TabletsIBA 04/2022
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2022
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2021

Therapy/Procedure

90	Therapeutics 01/2023 - 03/2003
13	Liver Transplantation 02/2019 - 06/2009
5	Duration of Therapy 09/2012 - 06/2004
4	Aftercare (After-Treatment) 05/2018 - 12/2002
3	Retreatment 01/2021 - 01/2017
3	Transplantation 01/2016 - 02/2010